The main purpose of this server is to allow individual and comparative analysis of protein interactions. We have developed a structural classification of protein binding regions at family level based on the structural classification of proteins, SCOP. The user can easily navigate through the classification till the family of interest, where all the interacting information is collected. Three hierarchical interaction levels are defined: family, binding region and interface levels. The binding regions are defined as distinctive surface regions of a protein family used to recognize other molecules. The interfaces distinguish the different partners or ligands that a specific region can recognize. Ligands include proteins, peptides, nucleic acids and saccharides.
Click here to immediately start using SCOWLP.
Please enter one of the following:
Use can use the filter to apply several restrictions to the choices shown below for better matching your interest.
Your can filter by the following categories:
Selecting all of a specific category will remove any existing restrictions for this category. To remove all existing restrictions at once just click reset all filters
Note: If you filter by more than one category, the results you get will have to match all of these restrictions.
Hint: To optimize the page space for analyzing the displayed information, you can minimize the filter without loosing the applied restrictions.
This is the linear representation of your current position within the SCOWLP hierarchy, starting by the structural classification of proteins levels (SCOP):
complemented with the interacting levels:
This line will always display your current "position" within this hierarchy. You can easily go back to a specific previous selection step by clicking on the according link. Selecting root will bring you back to the starting point of your search.
Note: If you click on one of the links, existing filters will remain active, until you select root
Use this inputs to control the marking of the interacting residues within the aminoacid sequences and alos in the viewer below.
Click here to switch between a more readable and a more compressed view of the aminoacid sequences.
Click here to choose a one-page layout optimized for interacting with the viewer.
Click here to choose a the standard one-page layout.
Click here to choose a one-page layout optimized for analyzing the aminoacid sequences.
Click here to choose a scrollable-page layout.
Our tutorial video will show you SCOWLP in action and help you doing your first steps inside SCOWLP.
You can start and stop the video every time you want by using the / buttons below. With the slider next to the buttons you can easily move to a specific position within the video.
Our slide show will give you a short introduction to SCOWLP and the terms you need to know to be able to work with SCOWLP.
You can start and stop the slide show every time you want by using the / buttons below. With the slider next to the buttons you can easily move to a specific slide.